منابع مشابه
Chemotherapy for malignant brain tumors of childhood.
During the past 3 decades, chemotherapeutic agents for the treatment of pediatric brain tumors have been extensively evaluated in a myriad of schedules, doses, and combinations. Remarkable advances in outcome have been achieved for certain children, notably those with medulloblastoma, but with a high cost to quality of life. In addition, the success achieved for medulloblastoma is offset by lac...
متن کاملChemotherapy for brain tumors.
Traditionally, cytotoxic drugs have played a limited role in the treatment of brain tumors, but important advances in chemotherapy have occurred during the past decade. Certain central nervous system (CNS) malignancies are remarkably chemosensitive. These include primary CNS lymphoma, medulloblastoma, oligodendroglioma, and intracranial germ-cell tumors. This review focuses on advances in the c...
متن کاملChemotherapy for Brain Tumors
悪性腫瘍 に対す る化学療 法の原則 には3通 りの仮定が あ る.第1は 治癒 するためにはすべての腫瘍 細胞が死滅 し,除 去 され なければな らない とす る説,第2は 生体 に は免疫学 的防御機構 が存 在す るか ら,あ る数 まで腫瘍 細 胞 を減 らす ことができれ ば,あ とは生体 の 自然 に備わ っ た防衛能 力で治癒 す ることができる とす る説,そ して第 3は,悪 性腫瘍 細胞を分化す ることがで きれば,た とえ 腫瘍 細胞が存 在 していて も増殖,転 移 によって生体 に悪 影響 を及ぼす ことな く,正 常組織 と平和共存で きるであ ろ うとする仮説 である.残 念 なが ら今 目,こ の仮説のい ずれが正 しいのか,そ の詳細は不明であ る.現 実的 には 悪性腫瘍 細胞 を減 らすためには5種 類 の治療 方 式 が あ る.す なわち,...
متن کاملChildhood Brain Tumors
Brain cancer is one of the most prevalent childhood cancers in the United States and Canada, second only to leukemia [1, 2]. The overall incidence of childhood brain tumors, the most common solid tumor in children, rose from 2.3 cases per 100,000 in 1975 to 3.0 cases per 100,000 in 1998 in the United States [1]. Similar rates were also seen in Canada [2]. One concern is that the elevated risk o...
متن کاملMalignant Brain Tumors in Childhood
Although most brain tumors are sporadic, a number of pediatric brain tumor presentations are associated with recognized genetic syndromes. About 15–20% of children with neurofibromatosis (NF1) present with CNS neoplasms, usually gliomas of the optic pathways or low-grade tumors of the diencephalon, cerebral hemispheres, or posterior fossa (2). Low-grade gliomas associated with NF1 may be less a...
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ژورنال
عنوان ژورنال: Current Pediatrics Reports
سال: 2013
ISSN: 2167-4841
DOI: 10.1007/s40124-013-0033-5